Demographic Profile and Treatment Outcomes of Filipino Patients with Hepatocellular Carcinoma in a Liver Tumor Registry

Ma. Lourdes O. Daez, Janus P. Ong, Allyn Rey B. Lomboy, Jeffrey M. Libuit,
Ivan Michael G. Vicente, Grace C. Firmalino and Gian Carlo A. Carpio

Section of Gastroenterology, Department of Medicine, College of Medicine and
Philippine General Hospital, University of the Philippines Manila

Background and Objectives. Previous studies using older diagnostic criteria indicated chronic Hepatitis B and alcohol as the most common etiologies of HCC in the Philippines. No recent studies using updated criteria for diagnosis have been published. This study used the diagnostic criteria from the latest APASL guidelines to describe the demographic profile of patients with HCC.

Methods. This is a cross-sectional study of adult HCC cases from a liver tumor registry in the Philippine General Hospital from 2009 to 2012. Demographics, AFP levels, BCLC stage, Child-Pugh Score, ECOG performance status, treatments received, and mortality were assessed.

Results. The HCC prevalence rate was 7.8%, mostly occuring between ages 40 and 65 years. It is more common in males (M:F=4:1). The most common risk factors are chronic Hepatitis B and alcohol use. Most of the HCC cases diagnosed at early stages, with less severity of liver functional impairment compared to older studies. Resection was the most common treatment undertaken (50%) and overall mortality rate at the time of hospital discharge was 25%.

Conclusion. The profile of HCC patients in this study is similar to previous studies. More cases were recognized at earlier stages with better liver function, implying better treatment outcomes with surgery, although selection bias is recognized.

Key Words: hepatocellular carcinoma, Filipino, demographic profile, treatment