Drug-induced Hypersensitivity Syndrome in an ANA-negative, anti-dsDNA-negative Systemic Lupus Erythematosus Patient

Ann Meredith U. Garcia,1 Geraldine Z. Racaza,1 Paolo S. Macasaet2 and Agnes D. Mejia1

1Department of Medicine, College of Medicine and
Philippine General Hospital, University of the Philippines Manila
2Department of Pathology, College of Medicine,
University of the Philippines Manila

A 50-year-old female presented with rash and multi-organ toxicity after intake of several antibiotics. This unmasked an elderly-onset, non-drug-induced seronegative systemic lupus erythematosus (SLE) which was confirmed by lupus band test (LBT) and skin biopsy staining. This patient presented with the rare combination of drug-induced hypersensitivity syndrome (DIHS) and SLE.

Key Words: drug-induced hypersensitivity syndrome, systemic lupus erythematosus, lupus band test