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Effect of Malunggay (Moringa oleifera) Capsules on Lipid and Glucose Levels
Mark Anthony S. Sandoval1,2 and Cecilia A. Jimeno1,3
1Section of Endocrinology, Diabetes and Metabolism, Department of Medicine,
College of Medicine and Philippine General Hospital, University of the Philippines Manila
2Department of Physiology, College of Medicine, University of the Philippines Manila
3Department of Pharmacology, College of Medicine, University of the Philippines Manila
Objectives. To determine the effect of malunggay leaf capsules on LDL (primary efficacy outcome measure); weight, BMI, FBS, serum glucose 2 hours after a 75 g oral glucose load, cholesterol, HDL and triglycerides (secondary efficacy outcome measures); creatinine, ALT and CBC (secondary safety outcome measures); and to determine if these are associated with adverse events.
Study design. randomized controlled trial
Participants. Seventy nine Filipinos, 18-55 years old with LDL>2.6 mmol/L (100 mg/dL) but of low cardiovascular risk were randomized into malunggay and placebo groups.
Intervention. Malunggay capsules for 30 days versus placebo
Results. 33 and 35 participants in the malunggay and placebo groups, respectively, completed the treatment. There was a reduction of 13.76 mg/dL in the LDL of the malunggay group, compared to a 19.28 mg/dL reduction in the placebo group (p=0.564).
Conclusion. Malunggay leaf capsules given for 30 days among adults with serum LDL >2.6 mmol/L (100 mg/dL) but with low cardiovascular risk decreased LDL levels to the same degree as placebo. There were no significant differences in the change in the secondary efficacy and safety outcome measures, and in the occurence of adverse events.
Key Words: Moringa oleifera, malunggay, LDL, cholesterol, dyslipidemia, lipid profile, glucose