Primary Mediastinal Liposarcoma of the Superior, Middle, and Anterior Mediastinum

Mary Ondinee U. Manalo and Gracieux Y. Fernando

Section of Medical Oncology, Department of Internal Medicine, College of Medicine and
Philippine General Hospital, University of the Philippines Manila

Primary liposarcomas constitute less than 1% of all mediastinal tumors. The posterior mediastinum is the location in 95% of cases. Literature search did not show a case that encompassed three mediastinal compartments.

A 32-year old man was diagnosed with high grade primary mediastinal liposarcoma (80% myxoid plus 20% round cell), after presenting with superior vena cava syndrome. CT-scan revealed lobulated masses on the superior, anterior, and the right middle mediastinum measuring 7.8 x 9.0 x 7.5 cm and compressing the superior vena cava. He underwent surgical debulking and palliative 3 cycles doxorubicin-based chemotherapy, but later succumbed to pneumonia.

Key Words: primary, mediastinal, liposarcoma