%PDF-1.3 1 0 obj << /Type /Catalog /Outlines 2 0 R /Pages 3 0 R >> endobj 2 0 obj << /Type /Outlines /Count 0 >> endobj 3 0 obj << /Type /Pages /Kids [6 0 R 20 0 R ] /Count 2 /Resources << /ProcSet 4 0 R /Font << /F1 8 0 R /F2 9 0 R /F3 10 0 R >> /XObject << /I1 11 0 R /I2 12 0 R /I3 24 0 R /I4 25 0 R /I5 28 0 R /I6 29 0 R /I7 32 0 R /I8 33 0 R /I9 36 0 R /I10 37 0 R /I11 40 0 R /I12 41 0 R /I13 45 0 R /I14 46 0 R /I15 50 0 R /I16 51 0 R /I17 55 0 R /I18 56 0 R /I19 59 0 R /I20 60 0 R /I21 61 0 R >> >> /MediaBox [0.000 0.000 595.280 841.890] >> endobj 4 0 obj [/PDF /Text /ImageC ] endobj 5 0 obj << /Creator (DOMPDF) /CreationDate (D:20180117212151+08'00') /ModDate (D:20180117212151+08'00') /Title (Cutaneous Drug Reactions in a Tertiary Government Hospital in the Philippines 2009-2011) >> endobj 6 0 obj << /Type /Page /Parent 3 0 R /Annots [ 14 0 R 16 0 R 18 0 R ] /Contents 7 0 R >> endobj 7 0 obj << /Length 3829 >> stream 1.000 1.000 1.000 rg 46.016 46.016 503.249 749.859 re f q 412.500 0 0 78.750 46.016 717.124 cm /I2 Do Q 0.000 0.000 0.000 rg BT 46.016 705.403 Td /F1 12.0 Tf [(Published on )] TJ ET BT 118.724 705.403 Td /F2 12.0 Tf [(Acta Medica Philippina : The National Health Science Journal)] TJ ET BT 444.860 705.403 Td /F1 12.0 Tf [( \()] TJ ET BT 46.016 690.751 Td /F1 12.0 Tf [(http://actamedicaphilippina.com.ph)] TJ ET 0.000 0.000 0.000 RG 0.6 w 0 J [ ] 0 d 46.016 688.351 m 230.768 688.351 l S BT 230.768 690.751 Td /F1 12.0 Tf [(\))] TJ ET BT 46.016 667.029 Td /F1 9.0 Tf [(Home)] TJ ET 0.45 w 0 J [ ] 0 d 46.016 665.229 m 70.019 665.229 l S BT 70.019 667.029 Td /F1 9.0 Tf [( > )] TJ ET BT 80.279 667.029 Td /F1 9.0 Tf [(Printer-friendly PDF)] TJ ET 0.45 w 0 J [ ] 0 d 80.279 665.229 m 159.290 665.229 l S BT 159.290 667.029 Td /F1 9.0 Tf [( > Printer-friendly PDF)] TJ ET 0.620 0.620 0.620 rg 46.016 658.081 503.249 0.750 re f 0.000 0.000 0.000 rg BT 46.016 618.558 Td /F3 24.0 Tf [(Cutaneous Drug Reactions in a Tertiary )] TJ ET BT 46.016 589.254 Td /F3 24.0 Tf [(Government Hospital in the Philippines )] TJ ET BT 46.016 559.950 Td /F3 24.0 Tf [(2009-2011)] TJ ET BT 46.016 526.288 Td /F1 12.0 Tf [(Submitted by Acta on Wed, 04/06/2016 - 9:51am)] TJ ET BT 103.912 499.636 Td /F2 12.0 Tf [(Carmela Augusta F. Dayrit, Clarita C. Maao and Michael Lawrenz F. Co)] TJ ET BT 100.558 472.984 Td /F1 12.0 Tf [(Section of Dermatology, Department of Medicine, College of Medicine and)] TJ ET BT 128.914 458.332 Td /F1 12.0 Tf [(Philippine General Hospital, University of the Philippines Manila)] TJ ET BT 295.972 431.680 Td /F1 12.0 Tf [()] TJ ET BT 46.016 405.028 Td /F1 12.0 Tf [(Objectives. To determine the frequency of Cutaneous Drug Reactions \(CDRs\), their )] TJ ET BT 46.016 390.376 Td /F1 12.0 Tf [(associated drugs, and morphological presentations in the Philippine General Hospital \(PGH\) )] TJ ET BT 46.016 375.724 Td /F1 12.0 Tf [(from 2009 to 2011 and to identify new or uncommon drugs causing CDRs.)] TJ ET BT 46.016 349.072 Td /F1 12.0 Tf [(Methods. This is a 3-year retrospective record review. The Naranjo algorithm was used to )] TJ ET BT 46.016 334.420 Td /F1 12.0 Tf [(score drug casuality.)] TJ ET BT 46.016 307.768 Td /F1 12.0 Tf [(Results. One hundred and forty-three \(143\) patient records were retrieved, with 218 )] TJ ET BT 46.016 293.116 Td /F1 12.0 Tf [(associated drugs identified. The most common drug classes were antibiotics \(29%\), anti-)] TJ ET BT 46.016 278.464 Td /F1 12.0 Tf [(tuberculosis medication \(17%\), and NSAIDs \(9%\). The most common drugs were isoniazid, )] TJ ET BT 46.016 263.812 Td /F1 12.0 Tf [(rifampicin, pyrazinamide, ethambutol \(HRZE\) combination drug \(9%\); amoxicillin \(6%\); and )] TJ ET BT 46.016 249.160 Td /F1 12.0 Tf [(contrimoxazole \(5%\). A morbiliform reaction \(49%\) was the most common morphological )] TJ ET BT 46.016 234.508 Td /F1 12.0 Tf [(presentation. There were several identified drugs, including anti-fungals and beta-blockers, )] TJ ET BT 46.016 219.856 Td /F1 12.0 Tf [(which caused a single drug reaction but had a sufficient Naranjo score to warrant inclusion.)] TJ ET BT 46.016 193.204 Td /F1 12.0 Tf [(Conclusions. The most common drug classes, drugs, and cutaneous morphological )] TJ ET BT 46.016 178.552 Td /F1 12.0 Tf [(presentations found in this study are similar to those seen in existing literature. However, )] TJ ET BT 46.016 163.900 Td /F1 12.0 Tf [(there were several drugs identified causing single drug reactions. This may reflect the need )] TJ ET BT 46.016 149.248 Td /F1 12.0 Tf [(for improved documentation, diagnosis, and follow-up of CDR cases in the PGH.)] TJ ET BT 46.016 122.596 Td /F2 12.0 Tf [(Key Words: drug reaction, adverse drug reaction, Naranjo Score, Philippines)] TJ ET endstream endobj 8 0 obj << /Type /Font /Subtype /Type1 /Name /F1 /BaseFont /Helvetica /Encoding /WinAnsiEncoding >> endobj 9 0 obj << /Type /Font /Subtype /Type1 /Name /F2 /BaseFont /Helvetica-Oblique /Encoding /WinAnsiEncoding >> endobj 10 0 obj << /Type /Font /Subtype /Type1 /Name /F3 /BaseFont /Helvetica-Bold /Encoding /WinAnsiEncoding >> endobj 11 0 obj << /Type /XObject /Subtype /Image /Width 550 /Height 105 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 550 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 6000>> stream x[nHշnm&!.JJJߧ (3ۘ j#։Ey-'"N,5kS"n)͊LD"H)JMJ2K#NGt k*Eiʩjһm&T)x?(SЛ(s.]P*XOhF=$)431_t"!h>IMbb$5}5 Y2'2') E:JؤixBcQlr$#-M$Iz䫥A`;MTyb#L< xK"[IzTfFDeB)Qf ց=Z UUI'"h%<{[蘯*N"nWM($O+:y|@mFyg,>G#}#GNk֌9t^Ew@ęy"Y]cn4][bPtSrYX_IyEgzUR˝׏W?#[܈$;2RI(@}Xz\X^r>`CR611͕$p"B-2oYQk :<M%XqB€(&d!4a}O5  b Xic<9D?JWX4)LC!Zz7a'A戏c)>]h UM]jIn`0O#R0 qcTM OoqMk#:yS=#8`jVc6S?)8485v6cׯz|VCo7&f}Ec HOo= r|z]ء:px?}]C]GvӃ׼40Aa^TʇmRꁎdvkc՝G}hΗQz^m?0;/a1!ߘ~){h\[L%ob>vN:}S! 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